Ethyl Acetate: Toxic chemical in After Shave lotions and Nail enamel removers.

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Ethyl acetate is a narcotic.

It also features on EPA hazardous waste list.

It is irritating to the eyes and respiratory tract, and may cause headache and narcosis (stupor), de-fatting effect on skin and may cause drying and cracking, anemia with leukocytosis and damage to liver and kidneys.

It is advisable to wash thoroughly after handling.

It is found in after shave lotions, cologne, perfume, shampoo, nail color ,nail enamel remover, fabric softener, dishwashing liquid.

Mifepristone: A Abortion Pill

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Mifepristone is the active ingredient of abortion pills. Mifepristone is a synthetic steroid compound used as a pharmaceutical. It is used as an abortifacient in the first two months of pregnancy, and in smaller doses as an emergency contraceptive. During early trials, it was known as RU-486, its designation at the Roussel Uclaf company, which designed the drug. The drug was initially made available in France, and other countries then followed—often amid controversy. It is marketed under tradenames Mifegyne and Mifeprex.

Disodium EDTA: Chelating Agent is Carcinogenic.

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Disodium EDT, a complex salt, may contain dangerous levels of ethylene oxide and or dixane, both of which are potent toxins and a manufacturing by- product.

It is used as chelating agent in quantitative analysis of metals in Research laboratories and chemical companies and Institutions.

It is carcinogenic.

Dioform: Harmful Chemical in toothpastes.

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Dioform is used in many toothpastes and other tooth whiteners.

It damages the teeth enamel and weakens the protective shell.

Diethanolamine: Toxic and Carcinogenic

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DEA (Diethanolamine) is a synthetic solvent used in detergents and humectant (moisturizer) soaps and allied products.

It is widely used in brake fluid, industrial degreaser and as an antifreezing agent.

Mostly used in liquid soap, shampoo and conditioner.

It can be harmful for the liver, kidneys and pancreas.

It may cause cancer in various organs.

It irritates skin, eyes, mucous membranes.

It is also found in hair dye, lotions, cream, bubble bath, liquid dishwashing detergent and laundry soap.

It creates health risk especially to infants and young children.

It also forms nitrosamines which are known to be carcinogens.

It causes allergic reactions and contact dermatitis.

It is hazardous and toxic.

Cocomidopropyl Betaine:Shampoos causes Eyelid dermatitis.

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Cocomidopropyl Betaine is used in shampoo in combination with other surfactants and synthetic chemicals.

It causes eyelid dermatitis.

Cocamide DEA: A Carcinogen in shampoos.

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(Cocamide diethanolamine) , a nitrosamine in all cosmetic ingredients is known to be carcinogen causing allergic reactions and contact dermatitis.

When it is applied to the skin, it is carcinogenic.

It is mostly found in shampoo.

The National Toxicology Program in the U.S. published in 1998 a study that topical skin application of cocamide DEA created in mice and rats liver tumours.

Phormia Regina feeding on Sugar droplet

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Phormia feeding on a droplet of sugar water colored red

Natural Cure for Jaundice.

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Jaundice is a yellow color in the skin, the mucous membranes, or the eyes. The yellow pigment is from bilirubin, a byproduct of old red blood cells.
It arises for many reasons, including blood incompatibilities, blood diseases, genetic syndromes, hepatitis, cirrhosis, bile duct blockage, other liver diseases, infections, or medications.

The following are the list of herbs which are known to have reputed action against liver disorders in particular Jaundice.

1. Azadirachta indica
2. Eclipta prostrata
3. Indigofera tinctoria
4. Phyllanthus acidus
5. Phyllanthus amarus
6. Phyllanthus urinaria
7. Terminalia chebula

AZADIRACHTA INDICA

English Name : Neem Tree
Family Name : Meliaceae
Parts Used : Root-bark, fruit or berry, seeds , flowers, leaves,
Oil and gum.
Action : Bitter, emetic, anthelmintic, astringent, stimulant
Chemical constituents : Active principle is a light yellow non-crystalline resinous substance without alkaloidal properties.
Uses : The leaf is made dried and is powdered well and to this half the part of Bishops weed (Carum copticum) and salt is added. This when given internally helps in curing jaundice.

ECLIPTA PROSTRATA

English Name : Trailing Eclipta
Family Name : Compositae
Parts Used : The whole plant
Action : Hepatic tonic, alterative, cholagogue, emetic
Chemical constituents : Ecliptine
Uses :·

The whole plant is made dried and is powdered well . This when given internally cures the disease.

The root powder is also used for enlarged liver , spleen, and dropsy.

INDIGOFERA TINCTORIA

English Name : Indian Indigo Plant
Family Name : Papilionaceae
Parts Used : Plant and expressed juice
Action : Antiseptic, astringent, antiperiodic, alterative,
Stimulant.
Chemical constituents : Indican, Indigotin.
Uses :

· The juice of the leaves mixed with honey is used in enlargement of liver and spleen.
· Also it is an antidote for various type of poisons.

PHYLLANTHUS ACIDUS

English Name : Country goose-berry
Family Name : Euphorbiaceae
Parts Used : The Whole plant
Action : Anti bilious, laxative, diaphoretic
Chemical constituents : Phyllanthine, Hypo phyllanthine and
Flavanoids(Quercetin)
Uses :

It is made into a paste with butter milk and given
Internally during early morning time for 3 to 4
Days . This subsides jaundice.

PHYLLANTHUS AMARUS

English Name : Indian Phyllanthus
Family Name : Euphorbiaceae
Parts Used : The whole plant
Action : Hepatic tonic, astringent, refrigerant
Chemical constituents : Phyllanthine, Hypo phyllanthine and
Flavanoids(Quercetin)
Uses :

The root of the plant is made into paste with milk .
This is given internally for jaundice.

PHYLLANTHUS URINARIA

English Name : Gripe weed, Shatterstone, or Leafflower
Family Name : Euphorbiaceae
Parts Used : The whole plant
Action : Tonic, astringent, diuretic
Chemical constituents : Phyllanthin
Uses :

The decoction of the whole plant cures the disease.

TERMINALIA CHEBULA

English Name : Chebulic myrobalan, ink nut
Family Name : Combretaceae
Parts used : Dried fruits
Action : Tonic, astringent,alterative,stomachic
Chemical constituents : Gallic acid, tannic acid, chebulinic acid.
Uses :

Chebulic myrobalans are used in fevers, cough, asthma, chronic diarrhoea, dysentry, colic and enlarged liver and spleen

List of Abbreviations used in Regulatory Affairs.

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ADR - Adverse Drug Reaction

ADME - Absorption, Distribution, Metabolism and Excretion

ADROIT - Adverse Drug Reactions On line Information Tracking

AI - Adverse Incident

AIMDD - Active Implantable Medical Devices Directive

AITS - Adverse Incident Tracking System

ARM - Application to Reclassify a Medicine

ASPPs - Anonymised Single Patient Print Outs

ASR - Annual Safety Report

ATC - Anatomical, Therapeutic, Chemical

BAN - British Approved Names

BLA - Biological License Application

BNF - British National Formulary

BP - British Pharmacopoeia

BSE - Bovine Spongiform Encephalopathy

CA - Competent Authority

CAPLA - Computer Assisted Product Licence Application

CANDA - Computer Assisted New Drug Application

CD - Controlled Drug

CEP - Central Enquiry Point, Certificate of European Pharmacopeia (certificate of suitability)

CFC - Chlorofluorocarbons

CJD - Creutzfeldt-Jakob Disease

CMC - Chemical, Manufacture and Control

CMS - Concerned Member State

CP - Centralised Procedure

CPP - Certificate of Pharmaceutical Product

CR - Computed radiology

CRO - Contract Research Organisation

CT - Computed tomography

CTA - Clinical Trial Application

CTC - Clinical Trials Certificate

CTD - Clinical Trials Directive, Common Technical Document

CTX - Clinical Trials Exemption scheme

DB - Device Bulletin

DCP - Decentralized Procedure

DDX - Doctors and Dentist Exemptions

DIR - Diagnostic Imaging Review

DMF - Drug Master File

DMRC - Defective Medicines Report Centre

DR - Digital radiology

EC - European Community

eCTD - electronic Common Technical Document

EEA - European Economic Area

EEC - European Economic Community

EP - European Pharmacoepia

EPAR - European Public Assessment Report

EPID - Extended Public Information Document

EQA - European Quality Award

ERA - Environmental Risk Assessment

EU - European Union

EUDRA - European Union Drug Regulatory Authorities

FOI - Freedom Of Information

GCP - Good Clinical Practice

GDP - Good Distribution Practice

GHTF - Global Harmonisation Task Force

GLP - Good Laboratory Practice

GLPMA - Good Laboratory Practice Monitoring Authority

GMDN - Global Medical Device Nomenclature

GMO - Genetically Modified Organism

GMP - Good Manufacturing Practice

GMPLA - Good Manufacturing Practice Licensing Authority

GP - General Practitioner

GPRD - General Practice Research Database

GPvP - Good Pharmacovigilance Practice

GSI - Government Secure Intranet

GSL - General Sale List

I&AC - Imaging and Acute Care

IC - Information Centre

ICES - Integrating Community Equipment Services

IM - Intramuscular

IM(ER)R - Ionising Radiation (Medical Exposure) Regulations

ImPACT - Imaging Performance Assessment of CT scanners

IMPD - Investigational Medicinal Product Dossier

IMS - Information Management Strategy

IMP - Investigational Medicinal Products

IND - Investigational New DrugI

NN - International Non-proprietary Names

IRR - Ionising Radiation Regulations

IVDD - In Vitro Diagnostic Directive

ISBN - International Standard Book Number

IUCD - IntraUterine Contraceptive Device

IUD - IntraUterine Device

IVDs - In Vitro Diagnostic Medical Devices

IT - Information Technology

IV - Intravenous

MA - Marketing Authorisation

MAA - Marketing Authorisation Application

MAIL - Medicines ACT Information Letter

MAL - Medicines Act Leaflet

MDA - Medical Device Alert

MDD - Medical Devices Directive

MDR - Medical Device Reporting, Medical Device Regulation

MDLO - Medical Device Liaison Officer

MEDDRA (MedDRA) - Medical Dictionary for Drug Regulatory Affairs

ML - Manufacturer's Licence

MORE - Manufacturer's On-line Reporting Environment

MP - Member of Parliament

MRA - Mutual Recognition Agreement

MRI - Magnetic Resonance Imaging

MRP - Mutual Recognition Procedure

MTL- Medicines Testing Laboratory

MTS - Medicines Testing Scheme

NAS - New Active Substance

NB - Notified Body

NCE - New Chemical Entity

NDA - New Drug Application

NOP - Non-Orthodox Practitioner

ODD - Orphan Drug Designation

OTC - Over-The-Counter products

P (medicine) - Pharmacy medicines

PAPs - Product Analysis Prints

PCT - Primary Care Trust

PD - Pharmacodynamy

PET - Positron Emission Tomography

PET/CT - Positron Emission Tomography and Computerised Tomography

PIL - Patient Information Leaflet

PIP - Paediatric Investigation Plan

PK - Pharmacokinetic

PL - Product Licence, Package LeafletPL (PI) - Product Licence (Parallel Import)

PLR - Product Licence of Righ

tPLUS - Product Licence User System

PMS - Post Marketing Surveillance

POM - Prescription Only Medicines

PPI - Patient Pack Initiative

PRRs - Proportioned Reporting Ratios

PSURs - Periodic Safety Update Reports

PUMA - Paediatric Use Marketing Authorisation

QA - Quality Assurance

QC - Quality Control

QOS - Quality Overall Summary

QP - Qualified Person

QRD - Quality Review of Documents

RAMA - Remote Access for Marketing Authorisations

R&D - Research & Development

rINN - Recommended International Non-proprietary Name

RMP - Risk Management Plan

RMS - Reference Member State

RP - Responsible Person

SABS - Safety Alert Broadcast System

SAMM - Safety Assessment of Marketed Medicines

SI - Statutory Instrument

SMF - Site Master File

SOP - Standard Operating Procedure

SPC or SmPC - Summary of Product Characteristics

SPECT - Single photon emission computed tomography

SSRIs - Selective Serotonin Reuptake Inhibitors

TCM - Traditional Chinese Medicine

THMPD - Traditional Herbal Medicinal Products Directive

THMRS - Traditional Herbal Medicines Registration Scheme

THR - Traditional Herbal Registration

TSE - Transmissible Spongiform Encephalopathy

USAN - United States Adopted Names

USP - United States Pharmacopeiav

AIC - Virtual Adverse Incident Centre

VAMF - Vaccine Antigen Master File

VMD - Veterinary Medicines Directorate

VTE - Venous ThromboEmbolism

WL - Wholesale Dealer's Licence

Coal Tar derivatives: A very Potential carcinogen used as FDC in Cosmetics.

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It is used in almost all shampoos formulated to treat dandruff and flaky scalp. It is also used in food colours for preparation of candies, lozenges.............

It is often disguised with names such as FD, FDC or DF&C colour.

It causes potentially severe allergic reactions, asthma attacks, fatigue, nervousness, headaches, nausea, lack of concentration, cancer, carcinogen, cough, redness of skin, burning sensation, can irritate nose, throat, hoarseness, nosebleeds, coughing, phlegm, changes in skin pigment and a rash.

A 2001 California study published in the International Journal of Cancer found that women who used to permanent hair dyes once a month were twice likely to develop bladder cancer!

There are many factors involved with hair colouring.

Studies in the U.S. have suggested that the chemical reaction created by hair cololuring products may be having a carcinogenic effect and have also associated hair colourings with an increased risk of Non-Hodgkin's lymphoma.

Try to avoid dark hair dyes entirely and choose products made with natural ingredients instead.

It is already Banned in EU cosmetics!

Benzaldehyde: A poisonous scenting agent.

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It is a narcotic, sensitizer, local anesthetic and CNS depressant.

It causes irritation to the mouth, throat, eyes, skin, lungs and GI tract, causing nausea and abdominal pain.

It may cause kidney damage.

Do not use it with contact lenses.

It is commonly found in perfume, cologne, hairspray, laundry bleach, deodorants, detergents, Vaseline lotion, shaving cream, shampoo, bar soap, dishwasher detergent.

It can also be smelt in the Appy Fizz drink, which is a soft drink.

Alpha-Terpineol: A Poisonous Scent in Soaps.

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It is highly irritating to mucous membranes.

Aspiration into the lungs can produce pneumonitis or even fatal edema.

It can also cause excitement, ataxia (loss of muscular coordination), hypothermia, CNS respiratory depression, headache.

It is advisable to prevent repeated or prolonged skin contact.

It is found in perfume, cologne, laundry detergent, bleach powder, laundry bleach, fabric softener, stickup air freshener, Vaseline lotion, soap, hairspray, after shave, roll-on deodorant.

Acetone: A chemical solvent used in cosmetics.

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Acetone features on EPA, RCRA, CERCLA hazardous waste list.

Inhalation of acetone can cause dryness of the mouth and throats, dizziness, nausea, in coordination, slurred speech, drowsiness, and, in severe exposures, coma.

It acts primarily as a central nervous system (CNS) depressant.

It is found in cologne, dishwashing liquid, detergent, nail enamel remover.

Acetamide MEA: Moisturiser, a slow killer.

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Acetamide MEA is also known as N-Acetyl acid amide or N-Acetyl ethanolamine.

It is used in lipsticks and cream blusher to retain moisture.

It causes adverse reactions.

It is carcinogenic, mutagenic, toxic.

Clementiny: The world's smallest Citrus fruit

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The world's smallest citrus fruit - a third the size of its larger cousin at just 4 cms wide and 2 cms high - is now available in Britain.


It is now being sold in the Tesco Supermarket chain which is also noffering other mini fruits, including mini bananas and mini mangoes, as part of the Christmas range.


It is believed that it will appeal to children because of its easy-to-peel skin, absence of pips and high juice content.

Selenium sulfide in shampoos erodes Gold Ornaments and jewelries.

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Selenium sulfide, which is used in shampoos for the treatment of Dandruff and scalp dermatitis, is used for the extraction of Glod, Silver and Copper.

It also has potential side effects. Use of Selenium sulfide can cause skin irritation, dry skin, hair loss, can irritate eyes on contact with possible eye damage, high exposure may cause headache, nausea, vomiting, garlic odour of breath, metallic taste, and coated tongue, known to cause cancer, may damage the liver and kidneys, prolonged exposure may casue pallor, nervousness and mood changes.

However, the most dangerous property of this compound, when used in shampoo is that it can erode the Gold Ornaments or jewelry that is worn.

Hence, a caution notice is given along with the shampoo on the usage leaflets or on the bottle stating that Gold ornaments should not be worn while administration.

One such shampoo is manufactured by Glenmark Pharmaceuticals.

Gold Uses in Aerospace and NASA

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If you are going to spend billions of dollars on a vehicle that when launched will travel on a voyage where the possibility of lubrication, maintenance and repair is absolutely zero, then building it with extremely dependable materials is essential. This is exactly why gold is used in hundreds of ways in every space vehicle that NASA launches.


Gold is used in circuitry because it is a dependable conductor and connector. In addition, many parts of every space vehicle are fitted with gold-coated polyester film. This film reflects infrared radiation and helps stabilize the temperature of the spacecraft. Without this coating, dark colored parts of the spacecraft would absorb significant amounts of heat.


Gold is also used as a lubricant between mechanical parts. In the vacuum of space, organic lubricants would volatilize and they would be broken down by the intense radiation beyond Earth's atmosphere. Gold has a very low shear strength and thin films of gold between critical moving parts serves as a lubricant - the gold molecules slip past one another under the forces of friction and that provides a lubricant action.

Gold used in Computers

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Gold is used in many places in the standard desktop or laptop computer.

The rapid and accurate transmission of digital information through the computer and from one component to another requires an efficient and reliable conductor. Gold meets these requirements better than any other metal. The importance of high quality and reliable performance justifies the high cost.


Edge connectors used to mount microprocessor and memory chips onto the motherboard and the plug-and-socket connectors used to attach cables all contain gold. The gold in these components is generally electroplated onto other metals and alloyed with small amounts of nickel or cobalt to increase durability.

Synthesis of Triacontanol: Plant Growth Regulator

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Triacontanol is a plant Growth regulator. It was also extracted from the waxy leaves of the plant, Medicago sativa also known as Alfalfa.

It is manufactured by many agrochemical companies in India. One such company is Universal speciality Chemicals.

Seaweed Granules manufacturers

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Seaweed granules (Ascophyllum nodosum) is a very effective fertilizer supplement to help restore the soil and nutrient conditions. It increases in biological activity and stimulates seed germination. It helps in better absorption of soil nutrients by plants. It increases the development of radicular system and stimulates chlorophyll formation.


List of Seaweed Granules manufacturers:
East Coast Seaweed Inc
Chaitanya Biologicals Pvt. Ltd.
Solufeed Plant Products & Services Pvt. Ltd.
Vanashree Agriculture Pvt. Ltd. (Vanashree Agrotech)
Universal Speciality Chemicals Private Limited
Go Organic
Varuna Bio Products
Aquatic Chemicals
V Kumar And Sons
Vardhaman Fertilizers & Seeds Private Limited
Agri Bio Care India
Hifield- AG Chem India Private Limited
VMJ Agrochemicals
Shri Murudeshwar Chemicals
Khandelwal Biotechnology Laboratory
Hi- Tech Bio Organics
Leeds Kem
Vashi Exports
Agri Business & Consultants
Forenta Agritech Corporation
Suboneyo Chemicals Pharmaceuticals (P) Limited
Viggi Agro Products
Kisan Group of Companies, Ahmedabad
Patil Krushi Udyog
Triagni Organic Life Enterprise
Marine Bio Products

Nitrobenzene 20%: List of Manufacturers

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Nitrobenzene is a flowering stimulant which is very effective in increasing flowering and also enhances early flowering and fruiting. total yield and the quality of the product depends on the use of Nitrobenzene.

List of Nitrobenzene manufacturers:
Tender Sips
Agrocare India Private Limited
Yash Chemicals
Mandar Agrotech
Viggi Agro Products
Surya Organics & Chemicals
Samir Tech-Chem Private Limited
Clarisis Organics Limited
Sadhana Nitro Chem Limited
VMJ Agrochemicals
Bhaskar Agro Chemicals Limited
Ascent Agrochem Private Limited
Nahar Agro World
Shree Venkatesha Agro Industries
Khandelwal Biotechnology Laboratory

Plant Micronutrients: List of Manufacturers

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Zn-EDTA

Fe-EDTA

Cu-EDTA

Mn-EDTA

Ca-EDTA

Mg-EDTA

The above plant micronutrients are very effective for the correction of defeciencies of nutrients in plants.

Micronutrients increases the yield of crops and thus the agricultural productivity.

micronutrients are used in combination of chelated/Unchelated metals depending upon soil condition, defeciencies of metals and other crops. etc.

List of plant Micronutrient manufacturers:

Xiamen Chemical Industry Co , Ltd

Xiamen Aolei Import And Export Co., Ltd.

Shandong Qindao Chem Factory

Yichang Municipal Pacific Chemicals Co., Ltd.

SUZHOU LIANSHENG CHEMISTRY CO., LTD

Sichuan Highlight Fine Chemicals Co., Ltd.

LIAOYANG TIANYUAN CHEMICAL PLANT

Qingdao Galaxy Nova Int'l Trade Co., Ltd.

Widezone International (Hongkong)Co., Ltd

Qingdao Golconda Trade Co Ltd

Kingsci Biotechnology Co., Ltd

Universal Impex Corporation

CHANGZHOU DAYUAN CHEMICAL CO., LTD

KY Chemicals Co., Ltd

Sichuan Arts & Crafts Import & Export Corporation

A&F INTERNATIONAL CO.,

Henan Yuzhongao Technological Agriculture Co., Ltd

Changheng Chemicals Ltd

First Vita Plus Philippines

Suzhou Liansheng Chemistry Co., Ltd

Lianhua Chemicals Co., Ltd.

Nanchang Changmao Chemical Industry Co., Ltd

China Hunan Common Future Arts & Crafts Corp Ltd – Chemical Dept

Shandong Tianci International Trading Co., Ltd. Beijing Branch

Yichang Municipal Pacific Chemicals Co., Ltd.

Gujarat Boron Derivatives Pvt. Ltd

Chakradhar Chemicals Pvt. Ltd.

Herb based chemical for Cancer from Club moss Lycopodium serratum: Serratezomine A an alkaloid

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Club moss Lycopodium serratum is a flowerless plant whose potent brew of alkaloids, which could have anticancer properties and may combat memory loss, have drawn considerable scientific and medical interest. Now, scientists have made one of these alkaloids in a laboratory, in a quantity sufficient for use. However, the plant makes many of these compounds in extremely low amounts, hindering efforts to to test their therapeutic value. That is no longer a problem for what is arguably the most complex of these alkaloids, a compound called Serratezomine A - an alkaloid that could have anti-cancer properties and may tackle memory loss. A team of synthetic chemists at Vanderbilt University reported that they have created an efficient way to make this molecule from scratch. It took six years for the researchers to develop the process because the researchers had to invent some entirely new chemical methods to complete the synthesis. These methods should make it easier to synthesize other Lycopodium alkaloids as well as other natural compounds wiith therapeutic potential.

Besides therapeutic possibilities, the researchers were attracted to other compounds which were among the most intricately structured and functionally dense of all the small molecules produced by living organisms. the compounds consist of carbon and Nitrogen atoms assembled in unique ring structures.

It took years to develop a new chemical reaction and then apply it to the natural product target.
In the world of total synthesis chemistry, it is not enough to figure out a way to synthesize a naturally occuring molecule. The process has to produce large enough quantities of the molecule that it can be tested for biological activity. that means that the number of sequential steps in the process - what chemists refer to as the Longest linear Sequence - should be as small as possible to maximise production.

For example, if a sequence has 30 steps and each step has an 80 percent yield, the overall yield of the sequence is about a tenth of one percent. At the same time. one low-yield step will knock a process out of contention.
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